Cardiovascular signals such as photoplethysmography (PPG), electrocardiography (ECG), and blood pressure (BP) are inherently correlated and complementary, together reflecting the health of cardiovascular system. However, their joint utilization in real-time monitoring is severely limited by diverse acquisition challenges from noisy wearable recordings to burdened invasive procedures. Here we propose UniCardio, a multi-modal diffusion transformer that reconstructs low-quality signals and synthesizes unrecorded signals in a unified generative framework. Its key innovations include a specialized model architecture to manage the signal modalities involved in generation tasks and a continual learning paradigm to incorporate varying modality combinations. By exploiting the complementary nature of cardiovascular signals, UniCardio clearly outperforms recent task-specific baselines in signal denoising, imputation, and translation. The generated signals match the performance of ground-truth signals in detecting abnormal health conditions and estimating vital signs, even in unseen domains, while ensuring interpretability for human experts. These advantages position UniCardio as a promising avenue for advancing AI-assisted healthcare.

We present a novel method for inferring ground-truth signal from multiple degraded signals, affected by different amounts of sensor "exposure". The algorithm learns a multiplicative degradation effect by performing iterative corrections of two signals solely from the ratio between them. The degradation function d should be continuous, satisfy monotonicity, and d(0) 1. We use smoothed monotonic regression method, where we easily incorporate the aforementioned criteria to the fitting part. We include theoretical analysis and prove convergence to the ground-truth signal for the noiseless measurement model. Lastly, we present an approach to fuse the noisy corrected signals using Gaussian processes. We use sparse Gaussian processes that can be utilized for a large number of measurements together with a specialized kernel that enables the estimation of noise values of all sensors. The data fusion framework naturally handles data gaps and provides a simple and powerful method for observing the signal trends on multiple timescales (long-term and short-term signal properties). The viability of correction method is evaluated on a synthetic dataset with known ground-truth signal.